•Corey Sisyphus comes to see you in clinic for follow-up. He holds a history of depression that was previously well-controlled on fluoxetine monotherapy. He’s had recent social stressors and reports always feeling stressed – like he’s constantly fighting up hill. He reports worsening fatigue, poor sleep, and depressed mood.
•Corey is requesting additional help. You notice that he is at the max dose for fluoxetine (so increasing his current medication is not an option). You’ve also noticed a lot of your peers have been prescribing duloxetine for their depressed patients, and you consider the same in this situation.
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•Wanting to make a full assessment of the risks for adding a new medication, you decide to see if there are any potentially drug-drug interactions.
•Go to Drugs.com
•At the top, click “Drug Interaction Checker”
•Type in each medication and add them to the list
•Hit “Check Interactions”
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•What serious drug-drug interaction immediately pops up?
•A) Diffuse drug rash
•B) Prolonged QT
•C) Serotonin Syndrome
•D) Diffuse neuropathy
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